Anti-cryptosporidial activity of Camellia sinensis (green tea extract) in experimentally infected immunocompromised mice
نویسندگان
چکیده
Cryptosporidium parvum, an Apicomplexan parasite, is important cause of diarrheal disease, especially in immunodeficient hosts. Nevertheless, there no entirely successful therapeutic agent against cryptosporidiosis to date. Hence, this study aims test the potential prophylactic and effect Camellia sinensis (green tea extract) dexamethasone immunosuppressed mice versus nowadays used drug, Nitazoxanide (NTZ). Parasitological molecular methods were characterize oocysts before infection. Fifty bred female Swiss Albino divided into 5 groups; group I (GI)(GTP): prophylactically treated with green extract for days prior infection, II (GII)(GTT): immunosuppressed, infected parvum extract, III (GIII)(NT): NTZ, IV (GIV)(PC): (Positive control), V (GV)(NC): non-infected (Negative control). Furthermore, parasitological examination stool, histopathological small intestine liver specimens performed groups. induction infection proved be genotype 2. Moreover, a significant oocyst reduction fecal samples correlated improvement changes intestinal tissues GI(GTP), GII (GTT) GIII(NT) Besides, GII(GTT) showed best parameters among This revealed that has activity could serve as promising anti-cryptosporidial agent.
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ژورنال
عنوان ژورنال: Acta Protozoologica
سال: 2022
ISSN: ['1689-0027', '0065-1583']
DOI: https://doi.org/10.4467/16890027ap.22.002.16205